Tray Dryer Powder Containment


Tray Dryers are a common method of dryer wetcakes and granulated drug products. This is especially true in the early product development phase.

Tray Dryers are a common method of dryer wetcakes and granulated drug products. This is especially true in the early product development phase. The issue of containment for this type of process equipment is unique in that open scooping of powder onto multiple trays that get slotted into the dryer one at a time prohibits a mass, single transfer as with charging a vessel through a nozzle.

There are many styles of Tray Dryers on the Market and installed that drive the Engineering Control here to a custom design. However, containment is accomplished with a standard set of interface and design techniques.

The various styles of dryers, interfaces, door types, volumes, ergonomics, and life cycle costs must all be taken into account in order to meet the need of containing the dryer. Included here is whether the dryer is portable or a fixed installation.

The final design may vary from operation to operation but a typical installation includes adding a flange to the face of the dryer to the outside of the door. An enclosure made from the rugged ArmorFlex family of films is then attached to the flange and a supporting frame assembly. These features will allow for opening the door within an enclosed environment when loading and unloading the trays with the drug product.

The trays, drug product and associated process tools can either be preloaded into the enclosure or bagged into the isolated area via bag in/bag out (BIBO) canisters or larger drum ring attachment canisters. The steps outlined below represent a typical example of this type of process:

  • Attach the enclosure to the support frame using the bungee cords supplied. Also attach the enclosure to the BIBO canister.
  • Preload trays into the enclosure (or bag in after the enclosure is attached)
  • Attach the enclosure to the flange on the dryer using the tape and V-Groove trim method developed by ILC and open the dryer door
  • Load the bags of wet cake material into the enclosure through a bag-in sleeve
  • Scoop material from the bags onto the dryer trays, load the trays into the dryer and close the dryer door for processing.
  • After the drying process is complete, open the door, remove the trays within the enclosure and scoop the powder into plastic bags which in turn will be placed through a bag-out sleeve. Alternatively, the powder can be scooped directly into a DoverPac, Continuous Liner, or Transfer Sleeve.
  • Crimp, cut a remove the contained materials for further processing.


After processing is completed, spray mist the inside of the enclosure as part of the overall wash down. The flexible enclosure will then be removed from the dryer while wearing personal protective equipment (PPE) as part of the wash down process.


  • Clear film allows use of existing light from the process area
  • Bungee cords and HEPA filters allow the enclosure to move with the operator
  • Static dissipative film supports ATEX and Ex operations
  • Re-usable for repeated processing of same drug product
  • Portable or permanent installations supported
  • Customized to specific process and equipment without change to drug product drying process



  • Ergonomics maximized for visibility, operator height and reach
  • No cross contamination transfer to other parts of the plant
  • Low capital, depreciation and operating costs maximizes true cost of ownership
  • Speed of implementation supports Lab and Production processes in any part of the plant
  • Reduced cleaning and cleaning validation
  • Product can be transferred between operations without breaking containment
  • No change in validation